Cytoxan oral-Cyclophosphamide (oral and injection) Uses, Side Effects & Warnings - e-seopro.com

Its mechanism of action probably involves antiangiogenetic effect rather than a classical antiproliferative effect like standard maximally tolerated dose-based regimens. All patients had hormonal therapy-resistant metastatic disease and had previously received two lines of chemotherapy. Toxicity was very mild and easily manageable. No cases of extra-hematological grade 3 toxicity were observed. Significant clinical activity was seen in heavily pretreated patients without severe grade side-effects.

In addition, dietary changes may help. Avoid sun exposure. For information about the 4th Angel Mentoring Program visit www. Do not use cyclophosphamide in larger or smaller amounts or for longer than recommended. Significant clinical activity was seen in heavily pretreated patients without severe grade side-effects. Discuss this issue with Cytoxan oral health care provider. See also: Cyclophosphamide drug Miniskirt stocking in Cytoxan oral detail. Cyclophosphamide can be harmful Cytpxan it gets on your skin. Cyclophosphamide is classified as an alkylating agent.

What is a road whore. Important Information

Retrieved 8 December European Journal Cytoxan oral Clinical Investigation Review. Inactive Ingredients. Clinical Pharmacokinetics. Development of sterility appears to depend on the dose of Cytoxan oral, duration of therapy, and the state of gonadal function at the time of treatment. Such preparations should be stored under refrigeration in glass containers and used Cytoxan oral 14 days. These adverse ora effects Chicago swing band remit when cyclophosphamide treatment is stopped. The adverse reactions are listed in order of decreasing incidence. Information on adverse reactions associated with the use of Cytoxan cyclophosphamide is arranged according to body system affected or type of reaction. In patients treated with cyclophosphamide-containing regimens for a variety of solid tumors, isolated case reports of Cytpxan malignancies have been published. Hemorrhagic cystitis may develop in patients treated with cyclophosphamide. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis division. We comply with the HONcode standard for trustworthy health information - verify here.

Classification: Alkylating Agent.

  • Generic name: cyclophosphamide mg in 25mL Dosage form: injection, powder, for solution; tablets.
  • Generic Name: cyclophosphamide Dosage Form: injection, powder, for solution; tablets.
  • Cyclophosphamide is the generic name for the trade name drug Cytoxan or Neosar.
  • Cyclophosphamide CP , also known as cytophosphane among other names, [3] is a medication used as chemotherapy and to suppress the immune system.
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Drug information provided by: IBM Micromedex. Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves mainly in children. Cyclophosphamide is also used for retinoblastoma a type of eye cancer mainly in children , multiple myeloma cancer in the bone marrow , and mycosis fungoides tumors on the skin. It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.

Some effects may not occur for months or years after the medicine is used. Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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European Journal of Rheumatology. Discuss this issue with your health care provider. The unchanged drug has an elimination half-life of 3 to 12 hours. Merriam-Webster Dictionary. Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy.

Cytoxan oral. How Cyclophosphamide Is Given

Toggle navigation. Spanish About Chemocare. What Cyclophosphamide Is Used For Cancers treated with cyclophosphamide include: Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic lymphocytic leukemia CLL , chronic myelocytic leukemia CML , acute myeloid leukemia AML , acute lymphocytic leukemia ALL , t-cell lymphoma mycosis fungoides , multiple myeloma, neuroblastoma, retinoblastoma, breast cancer, ovarian cancer, and conditioning regimens for bone marrow transplantation Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Cyclophosphamide Is Given The amount of cyclophosphamide that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have.

Your doctor will determine your exact dosage and schedule. Cyclophosphamide can be given by a number of different routes. The route that it is given depends on the dosage, the condition being treated, as well as the purpose it is being used for. It is usually given through a vein by injection or infusion intravenous, IV or by mouth in tablet form, depending upon diagnosis.

Cyclophosphamide is also approved to be given by a shot into a muscle IM , into the abdominal lining intraperitoneal, IP , or into the lining of the lung intrapleural. Tablets should be given with food or after meals. Tablets should not be cut or crushed. Side Effects Important things to remember about the side effects of cyclophosphamide: Most people will not experience all of the cyclophosphamide side effects listed.

Cyclophosphamide side effects are often predictable in terms of their onset, duration, and severity. Cyclophosphamide side effects will improve after therapy is complete. Cyclophosphamide side effects may be quite manageable. There are many options to minimize or prevent the side effects of cyclophosphamide. Onset: 7 days Nadir: days Recovery: 21 days Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts.

Hair loss : Temporary - usually begins weeks after the start of therapy. Nausea and vomiting : more common with larger doses, usually beginning hours after therapy.

Discuss this issue with your health care provider. Diarrhea Mouth sores Bladder irritation and bleeding hemorrhagic cystitis see bladder problems Delayed Effects of Cyclophosphamide: There is a slight risk of developing a blood cancer such as leukemia or myelodysplasia after taking cyclophosphamide. Talk to your doctor about this risk. When to Contact Your Doctor or Health Care Provider Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of Contact your health care provider within 24 hours of noticing any of the following: Nausea interferes with ability to eat and unrelieved with prescribed medication Vomiting vomiting more than times in a hour period Diarrhea episodes in a hour period Unusual bleeding or bruising Black or tarry stools, or blood in your stools Blood in the urine Pain or burning with urination Extreme fatigue unable to carry on self-care activities Mouth sores painful redness, swelling or ulcers Always inform your health care provider if you experience any unusual symptoms.

Precautions Before starting cyclophosphamide treatment, make sure you tell your doctor about any other medications you are taking including prescription, over-the-counter, vitamins, herbal remedies, etc. Do not take aspirin or products containing aspirin unless your doctor specifically permits this. Do not receive any kind of immunization or vaccination without your doctor's approval while taking cyclophosphamide.

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Cyclophosphamide may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.

For both men and women: Use contraceptives, and do not conceive a child get pregnant while taking cyclophosphamide. Barrier methods of contraception, such as condoms, are recommended for up to one year after last dose of cyclophosphamide.

Do not breast feed while taking cyclophosphamide. Self-Care Tips Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise. It is important to void empty your bladder frequently especially in the first 24 hours after taking cyclophosphamide. Report any pain or burning on urination to your health care provider. You may be at risk of infections so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.

Use an electric razor and a soft toothbrush to minimize bleeding. Avoid contact sports or activities that could cause injury. To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals. Eat foods that may help reduce diarrhea see managing side effects - diarrhea. Avoid sun exposure. Wear SPF 30 or higher sunblock and protective clothing. In general, drinking alcoholic beverages should be kept to a minimum or avoided completely.

You should discuss this with your doctor. National Cancer Institute. Archived from the original on 25 April Retrieved 20 December Archived from the original on 2 January Retrieved 8 December European Journal of Rheumatology. World Health Organization. April Archived PDF from the original on 13 December International Drug Price Indicator Guide.

Archived from the original on 10 May British Medical Association. Centers for Medicare and Medicaid Services. Archived from the original on 21 December London, UK: Pharmaceutical Press. Retrieved 12 August American Journal of Hematology. British Journal of Haematology. Bone Marrow Transplantation. Seminars in Hematology.

American Journal of Medical Genetics. The Journal of Rheumatology. BMC Medicine. Clinics in Chest Medicine. Two distinct patterns". Journal of Clinical Oncology. Archives of Internal Medicine. Nature Reviews. Clinical Oncology. Arthritis and Rheumatism. Insights from three cases complicating autoimmune diseases". European Journal of Clinical Investigation Review. Lupus nephritis". Annals of Internal Medicine. Clinical Pharmacokinetics.

A year followup study". American Society of Hematology. Education Program. The Journal of Pharmacology and Experimental Therapeutics. Pharmacological Reviews. Kidney International. Cancer Treatment Reports. Annales Francaises d'Anesthesie et de Reanimation in French. INIST : Blood Reviews. Biochemical Pharmacology. Seminars in Immunopathology.

Journal of the American Chemical Society. Current Pharmaceutical Design. Chemotherapie maligner Tumoren [ Chemotherapy of malignant tumors ]. Asta-Forschung und Therapie in German. Strahlentherapie in German. Seventh Cain Memorial Award lecture". Cancer Research. BMC Infectious Diseases. Archived from the original on International Immunopharmacology. Dihydrofolate reductase inhibitor Aminopterin Methotrexate Pemetrexed Pralatrexate Thymidylate synthase inhibitor Raltitrexed Pemetrexed.

Ribonucleotide reductase inhibitor Hydroxycarbamide. Podophyllum Etoposide Teniposide. Streptomyces Actinomycin Bleomycin Mitomycins Plicamycin. Xenobiotic-sensing receptor modulators. Pharmacy and pharmacology portal Medicine portal. Namespaces Article Talk. Views Read Edit View history.

Cyclophosphamide is the generic name for the trade name drug Cytoxan or Neosar. In some cases, health care professionals may use the trade name Cytoxan or Neosar when referring to the generic drug name cyclophosphamide. Drug Type: Cyclophosphamide is an anti-cancer "antineoplastic" or "cytotoxic" chemotherapy drug. This medication is classified as an "alkylating agent.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. Note: Not all side effects are listed above. Side effects that are very rare - occurring in less than about 10 percent of patients - are not listed here. But you should always inform your health care provider if you experience any unusual symptoms.

Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:. The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:. You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy.

Periodic blood work will be obtained to monitor your complete blood count CBC as well as the function of other organs such as your kidneys and liver will also be ordered by your doctor. Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue.

Cancerous cells lose this ability. Cancer cells no longer have the normal checks and balances in place that control and limit cell division. The process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis division. The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. If the cells are unable to divide, they die.

The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide self-death or apoptosis. Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective.

This is why chemotherapy is typically given in cycles. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. Chemotherapy will kill all cells that are rapidly dividing. Different drugs may affect different parts of the body.

Cyclophosphamide is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific.

There are several types of alkylating agents. Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not substitute for medical advice.

For more information about cyclophosphamide, see FDA prescribing information or package insert. For information about the 4th Angel Mentoring Program visit www. Toggle navigation. Spanish About Chemocare. What Cyclophosphamide Is Used For Cancers treated with cyclophosphamide include: Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic lymphocytic leukemia CLL , chronic myelocytic leukemia CML , acute myeloid leukemia AML , acute lymphocytic leukemia ALL , t-cell lymphoma mycosis fungoides , multiple myeloma, neuroblastoma, retinoblastoma, breast cancer, ovarian cancer, and conditioning regimens for bone marrow transplantation Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Cyclophosphamide Is Given The amount of cyclophosphamide that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have.

Your doctor will determine your exact dosage and schedule. Cyclophosphamide can be given by a number of different routes. The route that it is given depends on the dosage, the condition being treated, as well as the purpose it is being used for. It is usually given through a vein by injection or infusion intravenous, IV or by mouth in tablet form, depending upon diagnosis.

Cyclophosphamide is also approved to be given by a shot into a muscle IM , into the abdominal lining intraperitoneal, IP , or into the lining of the lung intrapleural. Tablets should be given with food or after meals. Tablets should not be cut or crushed. Side Effects Important things to remember about the side effects of cyclophosphamide: Most people will not experience all of the cyclophosphamide side effects listed.

Cyclophosphamide side effects are often predictable in terms of their onset, duration, and severity. Cyclophosphamide side effects will improve after therapy is complete. Cyclophosphamide side effects may be quite manageable.

There are many options to minimize or prevent the side effects of cyclophosphamide. Onset: 7 days Nadir: days Recovery: 21 days Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. Hair loss : Temporary - usually begins weeks after the start of therapy. Nausea and vomiting : more common with larger doses, usually beginning hours after therapy. Discuss this issue with your health care provider.

Diarrhea Mouth sores Bladder irritation and bleeding hemorrhagic cystitis see bladder problems Delayed Effects of Cyclophosphamide: There is a slight risk of developing a blood cancer such as leukemia or myelodysplasia after taking cyclophosphamide.

Talk to your doctor about this risk. When to Contact Your Doctor or Health Care Provider Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of Contact your health care provider within 24 hours of noticing any of the following: Nausea interferes with ability to eat and unrelieved with prescribed medication Vomiting vomiting more than times in a hour period Diarrhea episodes in a hour period Unusual bleeding or bruising Black or tarry stools, or blood in your stools Blood in the urine Pain or burning with urination Extreme fatigue unable to carry on self-care activities Mouth sores painful redness, swelling or ulcers Always inform your health care provider if you experience any unusual symptoms.

Precautions Before starting cyclophosphamide treatment, make sure you tell your doctor about any other medications you are taking including prescription, over-the-counter, vitamins, herbal remedies, etc.

Do not take aspirin or products containing aspirin unless your doctor specifically permits this. Do not receive any kind of immunization or vaccination without your doctor's approval while taking cyclophosphamide. Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Cyclophosphamide may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.

For both men and women: Use contraceptives, and do not conceive a child get pregnant while taking cyclophosphamide. Barrier methods of contraception, such as condoms, are recommended for up to one year after last dose of cyclophosphamide. Do not breast feed while taking cyclophosphamide.

Self-Care Tips Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise. It is important to void empty your bladder frequently especially in the first 24 hours after taking cyclophosphamide. Report any pain or burning on urination to your health care provider. You may be at risk of infections so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.

Use an electric razor and a soft toothbrush to minimize bleeding. Avoid contact sports or activities that could cause injury. To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals. Eat foods that may help reduce diarrhea see managing side effects - diarrhea. Avoid sun exposure.

Wear SPF 30 or higher sunblock and protective clothing. In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor. Get plenty or rest. Maintain good nutrition. Remain as active as you are able. Gentle exercise is encouraged such as a daily walk. If you experience symptoms or side effects, be sure to discuss them with your health care team.

Monitoring and Testing While Taking Cyclophosphamide You will be checked regularly by your doctor while you are taking cyclophosphamide, to monitor side effects and check your response to therapy. How Cyclophosphamide Works Chemotherapy anti-neoplastic drugs : Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue.

Have questions about chemotherapy?